FFR2D
medLYTIC Labs have developed ultra-fast sophisticated mathematical computer models that analyze routine 2-dimensional instead of 3-dimensional angiographic images and can calculate reliably FFR within a few seconds (FFR2D). Our software performs not only a quick, but also completely non-invasive and wire-free calculation of Fractional Flow Reserve (FFR). We transform routine angiograms into objective vessel physiology, along with anatomic insights, providing all the information needed to help with medical decision making during percutaneous coronary intervention (PCI) treatment decisions.
medLYTIC Labs’ invention performs flow analysis of 2-dimensional angiographic images to calculate hyperemic pressure drops across arterial stenoses. The software derives an array of hemodynamic indices (including FFR and IMR) claiming several added value propositions such as:
- image-based wire-free analysis that avoids the need for invasive application of intravascular pressure wires or other catheters
- no need for pharmacological induction of hyperemia (vasodilator) of the coronary or other vessels
- application in standard two-dimensional X-Ray angiographic images, but also multiplanar angiographic images derived from other modalities like magnetic resonance, or computed tomography angiography
- ultra-fast computation process in the order of a few seconds compared to several minutes or even hours in case of competing technologies, and
- obviation of cumbersome, laborious and time-consuming 3-dimensional image reconstruction of vascular geometries
- holistic approach in assessment of cardiac physiology high probability of correct classification of critical epicardial stenoses and high precision measurements compared to other angio-based technologies or pressure-wire measurements themselves
- the pipeline allows for further determination of several physiological metrics like absolute coronary flow at rest and hyperemia, basal and hyperemic stenosis resistance, as well as basal and hyperemic microvascular resistance, and the index of microvascular resistance (IMR)
- The FFR2D pipeline applies also directly on cardiac CTA datasets for FFR-CT computations with improved ease and speed by downgrading complexity from the 3D framework to a 2D multiplanar imaging approach